Job Description

The Bharioke Lab at the Medical University of South Carolina is seeking a Postdoctoral Scholar to join our lab in the Department of Neuroscience. This position is ideal for individuals interested in applying cutting edge imaging and computational methods to answer important questions in circuits and developmental neuroscience. The lab focuses on understanding the rules underlying the organization and function of cortical circuits, throughout the lifespan of the mouse (bhariokelab.com). We employ a variety of techniques to accomplish these goals, in vivo, combining experimental approaches (deep tissue calcium imaging, optogenetics, and chemogenetics of neuronal populations) with creative computational analyses. Experience in some or all of these techniques (as demonstrated by prior work/publications) would be a plus, along with an inquiring mind and an enthusiasm for utilizing (and potentially improving) novel techniques. The ability to utilize computational methods to analyze large data sets will also be viewed as a plus, though the capacity to learn such computational methods, with the assistance of other lab members, will be necessary. The ideal individual for this position will work independently, with a drive to push past potential difficulties and come up with creative solutions. This individual should show initiative, be a self-starter and highly motivated, with a strong work ethic. We expect that any question that the individual will undertake to answer will be driven by the individual, with collaborative development of the original ideas together with the PI and other members of the lab. In support of this, strong communication skills are critical (and highly valued). This is both at the interpersonal level, to enable the individual to participate fully in the lab environment, as well as at broader levels, to initiate and drive potential collaborations within and beyond the department, and to communicate their science to a wider audience. Therefore, prior experience presenting scientific work would be viewed positively. A calm demeanor will also be a plus, as surgeries to enable imaging in embryos and adult mice require patience and fine motor skills and behavioral experiments with rodents are sensitive to experimenter stress. Job Duties: 35% Optical recordings and manipulations in head-fixed Mice: Learn and perform imaging from head-fixed mice using both one and two-photon microscopy, to obtain recordings of activity of genetically defined neurons and/or manipulate the activity of groups of genetically defined neurons. 25% Computational analysis of imaging data: Use programming languages, such as (but not limited to) MATLAB and Python, to design novel methods to analyze data derived from both imaging and behavioral experiments. 20% Conducting Behavioral Monitoring, Habituation, and Training in Mice: Design and train mice to perform cognitive tasks, reliant on one or more sensory inputs. This may include habituating mice to demonstrate changes in cognitive states (including transitions to and from unconsciousness, and transition to and from sleep), as well as monitoring mice during these changes, both with and without associated optogenetic and chemogenetic manipulations. 10% Conducting Surgical Procedures in Mice: Learn and perform cranial surgeries in both embryonic and/or adult mice, for the purpose of optical imaging and/or manipulations of neurons within cortex. Learn and perform viral injections to target genetically defined populations of neurons (using BSL2 level procedures). 10% Wet Lab Procedures: Postmortem tissue collection and processing for various assays, including (but not limited to) immunohistochemistry, RNAseq, and spatial transcriptomics. Physical Requirements include ability to perform job functions in various positions and conditions, ability to lift and carry up to 15 lbs., maintain sensory functions, and work in isolated areas. Additional requirements include ability to obtain and maintain a valid driver's license, computer literacy, ability to work rotating shifts and overtime, and ability to learn and use new processes, tools and equipment as required. The Medical University of South Carolina is an Equal Opportunity Employer and participates in the federal E-Verify program.

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